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Saturday, September 13, 2025

College Football Predictions and Schedule: Week 5 Top 25 Games Against the Spread and Odds

Week 5 of the 2024 College Football Season: A Clash of Titans

As we dive into Week 5 of the 2024 college football season, the excitement is palpable. Conference play is in full swing, and this week’s slate is packed with thrilling matchups, including four games featuring ranked teams. The highlight of the weekend is undoubtedly the showdown between No. 2 Georgia and No. 4 Alabama. Both teams are not only serious contenders in the SEC but are also early favorites in the national championship race. For Alabama’s first-year head coach, Kalen DeBoer, this game presents a golden opportunity to secure a signature win early in his tenure.

Key Matchups to Watch

Before the spotlight shines on the Georgia-Alabama clash, several other marquee games are set to unfold throughout the day.

No. 20 Oklahoma State at No. 23 Kansas State

Kicking off the action at noon ET, Oklahoma State travels to Kansas State in a pivotal Big 12 matchup. The game will likely hinge on the ground game, with Oklahoma State’s Ollie Gordon II, touted as a top rusher, facing off against Kansas State’s formidable trio of Giddens, Johnson, and Edwards. Oklahoma State’s recent performance against Utah highlighted their need for a consistent running game to compete at the highest level. Experts predict that Kansas State’s speed and skill will give them the edge in this contest, making them the favorites by a five-point margin.

No. 15 Louisville at No. 16 Notre Dame

At 3:30 p.m., the action continues with a critical matchup between No. 15 Louisville and No. 16 Notre Dame. Following a disappointing loss to Northern Illinois, Notre Dame rebounded with a resounding 66-7 victory over Purdue, showcasing their potential. This game is crucial for both teams’ playoff aspirations, as Louisville faces its toughest defensive challenge yet. Analysts believe that Notre Dame’s defense will stifle Louisville’s explosive plays, leading to a predicted seven-point victory for the Fighting Irish.

No. 19 Illinois at No. 9 Penn State

Later in the evening, No. 19 Illinois takes on No. 9 Penn State at 7:30 p.m. This matchup is significant for both teams in the context of the Big Ten standings. Illinois has been underrated, boasting a solid record against the spread, and they may surprise many by keeping the game closer than expected. While Penn State is favored to win, Illinois’ ability to exploit opportunities through the air could make this a competitive encounter.

The Main Event: No. 2 Georgia at No. 4 Alabama

As the sun sets, all eyes will be on Bryant-Denny Stadium for the highly anticipated clash between Georgia and Alabama. This matchup is steeped in history and rivalry, with both teams vying for supremacy in the SEC. Georgia enters the game with a slight edge, having had a bye week to prepare after a narrow victory against Kentucky. Meanwhile, Alabama is looking to prove themselves after a relatively easy schedule thus far.

The stakes are high, not just for conference bragging rights but also for the national championship picture. Both teams have shown flashes of brilliance this season, but questions linger about their true capabilities. Georgia’s recent performance has raised eyebrows, while Alabama seeks to establish their dominance. With the atmosphere in Tuscaloosa expected to be electric, this game promises to be a thrilling spectacle.

Expert Predictions and Insights

As we look ahead to these pivotal matchups, experts are weighing in with their predictions. The consensus seems to favor Kansas State over Oklahoma State, Notre Dame against Louisville, and a strong showing from Ohio State against Michigan State. However, the Georgia-Alabama game is where the most intrigue lies, with predictions split but leaning slightly towards Georgia.

The Upset Alert

Adding to the drama of Week 5, SportsLine’s computer model has identified a potential for 10 outright upsets across the board. This unpredictability is part of what makes college football so captivating. Fans and analysts alike will be glued to their screens, eager to see how the day unfolds and which teams will rise to the occasion.

Stay Tuned for All the Action

With a full slate of games and so much at stake, Week 5 of the 2024 college football season is shaping up to be one for the ages. Be sure to follow CBS Sports for comprehensive coverage, expert analysis, and live updates as the action unfolds. Whether you’re a die-hard fan or a casual observer, this weekend promises to deliver unforgettable moments and thrilling football.

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